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Blog Archive

Notes on Bayesian experimental design

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For much of the experimental design literature, Bayesian experimental design is synonymous with the expected Kullback-Leibler divergence. It is not obvious at first glance why this criterion leads to informative experiments, so let’s dive a bit deeper into Bayesian experimental design.

New paper about Experimental Design using the Kalman Filter

I am happy to announce the publication of our paper “Adaptive and robust experimental design for linear dynamical models using Kalman filter” in Statistical Papers.

Current experimental design techniques for dynamical systems often only incorporate measurement noise, while dynamical systems also involve process noise.

Design for model discrimination using symbolic regression

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Most experimental design focusses on parameter precision, where the model structure is assumed known and fixed. But arguably finding the correct model structure is the part of the modelling process that takes the most effort. In this blog we will look at automating this process using symbolic regression, and to do this with gathering too much data.

Notes on adjoint sensitivity analysis of dynamic systems part 1

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Gradients are useful for efficient parameter estimation and optimal control of dynamic systems. Calculating these gradients requires sensitivity analysis. Sensitivity analysis for dynamic systems comes in two flavors, forward mode and adjoint (reverse). For systems with a large number of parameters adjoint sensitivity analysis is often more efficient [1]. I find that the traditional way of deriving adjoints for ordinary differential equations, such as [3], leaves me with little intuition what these equations represent. The goal of this blog post is to gain some intuition about these equations by deriving the adjoint equations in a different way.